Most entities of the game have a much lower resistance to acid than other damage types (including turrets and armor), so spitters are effectively more potent against the player and their factories.
Both the stream and the puddle of acid deal damage of time and slow down players and vehicles. Due to the spitters' predictive aiming, the acid stream can be dodged by suddenly changing walking directions or standing still. Using predictive aiming, they spit a stream of acid at enemies which leaves behind a puddle of acid where it hits the ground. Their main difference from biters is their ranged attack. Spitters are much like biters and only appear slightly later on in the game as the evolution factor increases. Can attack through walls, hitting objects directly behind them. Extremely durable and nearly immune to small arms, except for the strongest ordnance.